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Dilaudid is a potent, prescription opioid analgesic used to treat moderate to severe pain when other treatments are inadequate. Its generic name is hydromorphone hydrochloride, and it is a Schedule II controlled substance due to its high potential for abuse and addiction. Key Information Active Ingredient: Hydromorphone, a semi-synthetic opioid structurally similar to morphine. Potency: It is significantly more potent than morphine, with an analgesic effect estimated to be 2 to 8 times greater. Indications: It is prescribed for pain that is severe enough to require an opioid and for which alternative treatments have failed or cannot be tolerated. For chronic pain, its use is often limited to cases like cancer pain. Forms and Administration: Dilaudid is available in several forms, including oral tablets, oral liquid, and injectable solutions (intravenously, intramuscularly, or subcutaneously). Mechanism of Action: It works by binding to opioid receptors in the brain and spinal cord, which decreases the perception of pain. Important Risks and Side Effects Addiction and Dependence: Dilaudid has a high risk of addiction, abuse, and misuse, which can lead to overdose and death. Physical dependence can develop even with prescribed use. Respiratory Depression: The chief hazard of Dilaudid is life-threatening respiratory depression (slow, shallow, or no breathing), especially when starting treatment or increasing the dose. Interactions: The risk of serious side effects, including severe sedation, respiratory depression, coma, and death, increases significantly when Dilaudid is used with other central nervous system (CNS) depressants, such as alcohol or benzodiazepines. Common Side Effects: Common side effects include lightheadedness, dizziness, sedation, nausea, vomiting, sweating, and constipation. Overdose Symptoms: Signs of an overdose require immediate emergency medical help and include severe drowsiness, pinpoint pupils, cold/clammy skin, slowed heart rate, and very slow or stopped breathing. Naloxone is a temporary rescue medication that can reverse an overdose. Usage Precautions Do not crush, chew, or dissolve extended-release tablets, as this can lead to an uncontrolled, fatal dose. Dosing should be individualized and monitored closely by a healthcare professional to balance pain management with the risk of adverse events. Do not stop taking Dilaudid abruptly if you are physically dependent, as this can cause severe withdrawal symptoms; the dosage must be tapered gradually under medical supervision. For more information on safe use and disposal, healthcare providers are part of a program called Opioid Analgesic REMS (Risk Evaluation and Mitigation Strategy). You can find detailed patient information on the FDA website.