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Tapentadol is a prescription pain medication used to treat moderate to severe acute pain and certain types of chronic pain, including neuropathic pain. It works through a dual mechanism: it acts on opioid receptors to reduce pain perception and also inhibits norepinephrine reuptake, which helps enhance pain control in the nervous system.

Because of this combined action, tapentadol may provide effective pain relief with a different side-effect profile compared to traditional opioids. It is available in immediate-release formulations for acute pain and extended-release versions for long-term pain management, depending on clinical needs.

Tapentadol is classified as a Schedule II controlled substance, meaning it has legitimate medical use but also a high potential for misuse, dependence, and addiction. Common side effects may include nausea, dizziness, drowsiness, constipation, headache, or dry mouth. Serious risks increase when taken in higher doses or combined with alcohol or other central nervous system depressants.

This medication should be taken only as prescribed by a licensed healthcare provider. Individuals with breathing disorders, head injuries, liver problems, or a history of substance misuse may require alternative pain treatments. Regular monitoring is important to ensure safety and effectiveness, especially during long-term use.