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Clonazepam 1mg cannot be bought online with digital convenience home routes as a Schedule IV controlled substance requiring a valid prescription from a DEA-registered US healthcare provider for panic disorder, seizures, or restless legs syndrome; prescription-free platforms constitute federal felony distribution under 21 U.S.C. § 841 with up to 20 years imprisonment.

Dosing starts at 0.25-0.5mg BID titrating to 1mg BID maximum 4mg/day divided under 2025 DEA telemedicine flexibilities expiring December 31, 2025—synchronous HIPAA video mandates PDSS ≥15 or EEG confirmation, multi-state PDMP clearance, QTc <450ms—no digital home route bypasses post-flex in-person initiation, EPCS authentication, ≤5 refills/6 months #30 tablets 1mg strength across 45 states.

High-Potency Nitrobenzodiazepine Pharmacology

GABA-A α2/α3 agonist (Ki 0.5nM), Tmax 1-4h, t½ 30-40h active 7-aminoclonazepam; black box: 40% dependence week 4, opioid OR10 respiratory depression, withdrawal seizures 20-30%—taper 0.125mg weekly 8-12 weeks CIWA-B monitoring; contraindications: glaucoma, COPD AHI>30, CYP3A4i x3 exposure.

Ryan Haight Compliance (Through 12/31/2025)

1. Diagnostic: PDSS ≥15 + 6-month history/EEG excluding mimics.

2. Video: PDMP clean, C-SSRS negative, orthostatics stable.

3. EPCS: #30 tabs 1mg ≤5 refills/6mo pharmacy-direct.

4. Delivery: Signature tamper-evident USPS Priority.

5. Monthly: ≥30% PDSS reduction + UDS surveillance.

Adverse Event Matrix

Digital convenience home route violates Ryan Haight no-exam prohibition—federal felony.