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What is Fioricet?
Fioricet is a prescription-only combination medication used to treat tension headaches and complex migraine episodes. A standard formulation contains:

Butalbital (50mg): A barbiturate sedative that relaxes muscle contractions and has a mild anxiety-reducing effect. It is a Schedule III controlled substance due to its potential for dependence and abuse.
Acetaminophen (300mg or 325mg): A pain reliever and fever reducer.
Caffeine (40mg): A stimulant that enhances the effects of the other ingredients and constricts blood vessels in the brain.

Important Note: The "50mg" designation in Fioricet typically refers to the butalbital component. It is not a standard monotherapy and is only available by prescription following a medical diagnosis.

Uses and Benefits
Fioricet is prescribed for the short-term relief of tension headaches that have not responded to regular over-the-counter pain medication. Its benefit comes from combining muscle relaxation, pain relief, and caffeine's amplifying effect to break the headache cycle.

Dosage and Administration

Typical Adult Dose: One to two capsules or tablets every 4 hours as needed for pain.
Maximum: Do not exceed 6 doses (or capsules) in 24 hours due to the risks of acetaminophen overdose and barbiturate dependence.
Tablets must be swallowed whole.
This is a short-term therapy (usually a few days) to avoid medication-overuse headaches and dependence.

Side Effects and Risks
Common effects:

Drowsiness, dizziness, lightheadedness
Nausea, vomiting, stomach upset
Feeling "intoxicated" or sedated

Serious risks:

Acetaminophen Toxicity: Exceeding the daily limit can cause severe liver failure, which can be fatal. This risk increases with alcohol use.
Barbiturate Dependence: Physical and psychological dependence can develop rapidly. Withdrawal can be severe, including seizures.
Respiratory Depression: Butalbital can slow or stop breathing, especially when mixed with alcohol, opioids, or other sedatives.
Allergic Reactions: Rash, swelling, or difficulty breathing.
Medication-Overuse Headache: Using this medication too frequently can lead to more frequent, rebound headaches.