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Methadone is a long-acting opioid medication prescribed for the treatment of severe chronic pain and used widely in opioid use disorder (OUD) treatment programs. It works by acting on opioid receptors in the brain, helping reduce pain and stabilizing individuals recovering from opioid dependency. ______________ What Methadone Is Used For 1. Opioid Use Disorder (OUD) Methadone is a key part of medication-assisted treatment (MAT). It helps: • Reduce withdrawal symptoms • Minimize cravings for opioids • Stabilize brain chemistry • Support recovery programs under clinical supervision It allows individuals to function normally without experiencing the highs and lows associated with opioid misuse. 2. Severe Chronic Pain Methadone may be prescribed for severe, persistent pain when other treatments are not effective. It provides long-lasting relief due to its extended duration in the body. ______________ How Methadone Works Methadone: • Binds to mu-opioid receptors to relieve pain and reduce cravings • Has a long half-life, providing steady effects • Prevents or reduces withdrawal symptoms in people dependent on opioids Its slow onset helps avoid the rapid “high” linked to misuse. ______________ Forms & Strengths Methadone is available as: • Tablets • Oral solution • Dispersible tablets • Injectable form (used in medical facilities only) Dosage varies based on individual medical needs and is strictly determined by a specialist. ______________ Common Side Effects Possible effects include: • Drowsiness • Nausea • Sweating • Constipation • Lightheadedness • Slowed breathing (higher risk with improper use) Severe symptoms require urgent medical attention. ______________ Warnings & Precautions Methadone is a controlled substance because of its opioid effects and potential for: • Dependence • Misuse • Overdose • Respiratory depression Important safety points: • Only take methadone under medical supervision • Avoid alcohol and other sedatives • Do not adjust dosage without medical direction • People with breathing problems, heart rhythm disorders, or liver issues need careful monitoring Stopping methadone suddenly can cause significant withdrawal; tapering must be supervised. ______________ Important Note Methadone should only be taken with a valid prescription and through approved medical programs when treating OUD. Misuse or unsupervised use can cause serious health risks, including overdose.