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Methadone is a long-acting opioid medication prescribed for two main purposes: 1. Managing moderate to severe chronic pain, especially when other treatments are not effective. 2. Medication-Assisted Treatment (MAT) for individuals with opioid use disorder (OUD), helping stabilize withdrawal symptoms and reduce cravings. Because of its long duration of action and predictable effects, methadone is used in carefully supervised treatment programs as well as in certain pain management plans. ______________ How Methadone Works Methadone binds to opioid receptors in the brain and spinal cord. This allows it to: • Relieve pain • Reduce withdrawal symptoms • Stabilize cravings in individuals recovering from opioid addiction • Produce a steadier, longer-lasting effect than many other opioids It does not produce the same rapid “high” as short-acting opioids when taken as prescribed. ______________ Common Medical Uses • Chronic pain management, especially neuropathic or cancer-related pain • Opioid use disorder treatment, as part of a structured program • Withdrawal stabilization during detoxification • Long-term maintenance therapy to support recovery and daily functioning ______________ Possible Side Effects Methadone may cause: • Drowsiness or dizziness • Nausea or vomiting • Constipation • Sweating • Dry mouth • Slower breathing (a serious risk at higher doses) Side effects are more likely during dose changes or when therapy begins. ______________ Safety Considerations • Methadone has a risk of overdose, especially when mixed with alcohol, benzodiazepines, or other sedatives. • Dosage adjustments must be done slowly because methadone stays in the body for a long time. • It can affect heart rhythm (QT prolongation), so monitoring may be required. • Never increase or stop the medication without medical supervision. • Patients being treated for OUD usually receive methadone through certified treatment programs to ensure safety. ______________ When to Seek Medical Attention Seek urgent help if you notice: • Slow or difficult breathing • Severe drowsiness or trouble staying awake • Chest pain or irregular heartbeat • Confusion or unusual behavior • Allergic reactions (rash, swelling, difficulty breathing)