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Methadone is a prescription opioid medication used for two primary purposes: the management of chronic severe pain and the treatment of opioid use disorder (OUD) as part of a medically supervised program. It is unique among opioids because of its long duration of action and its role in both pain control and addiction treatment.

Methadone works by binding to opioid receptors in the brain and nervous system, helping to reduce pain while also preventing withdrawal symptoms and cravings in individuals recovering from opioid dependence. When used in opioid treatment programs, methadone helps stabilize patients and supports long-term recovery when combined with counseling and medical monitoring.

Common side effects may include drowsiness, constipation, sweating, nausea, dizziness, and slowed breathing. Because methadone stays in the body for a long time, improper dosing can increase the risk of respiratory depression and overdose, especially when combined with alcohol, benzodiazepines, or other sedatives.

Methadone must be taken exactly as prescribed and requires careful dose adjustments by a qualified healthcare provider. Abrupt discontinuation can lead to withdrawal symptoms, so any changes in therapy should be done gradually under medical supervision.