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OxyContin (oxycodone hydrochloride) is a powerful, extended-release prescription opioid analgesic used to manage severe and persistent pain when continuous, around-the-clock treatment is needed for a long time. It is a Schedule II controlled substance due to its high potential for addiction, abuse, and misuse, which can lead to overdose and death. Key Information Active Ingredient: The primary active ingredient is oxycodone, a semi-synthetic narcotic derived from the opium poppy alkaloid thebaine. Mechanism: It works by binding to specific opioid receptors in the brain and spinal cord, changing how the body feels and responds to pain. Formulation: OxyContin is formulated as an extended-release tablet designed to release oxycodone slowly over 12 hours. It must be swallowed whole. Crushing, chewing, or dissolving the tablet defeats the controlled-release mechanism, leading to the rapid absorption of a potentially fatal dose of oxycodone. Indications: It is reserved for patients with severe pain for whom alternative treatments (e.g., non-opioid analgesics or immediate-release opioids) are inadequate. It is not intended for “as-needed” (prn) pain relief or for mild pain. Important Risks and Warnings The use of OxyContin carries several serious risks, highlighted by a boxed warning from the FDA: Addiction, Abuse, and Misuse: The potential for developing a substance use disorder, including addiction, is high, even when used as prescribed. Life-Threatening Respiratory Depression: This is the most serious potential side effect, where breathing becomes slow or shallow, especially when starting treatment or increasing the dosage. Accidental Ingestion: Even one dose ingested accidentally, particularly by a child, can be fatal. Interactions with other CNS Depressants: Using OxyContin with alcohol, benzodiazepines, or other central nervous system (CNS) depressants can cause profound sedation, respiratory depression, coma, and death. Neonatal Opioid Withdrawal Syndrome: Prolonged use during pregnancy can cause life-threatening withdrawal symptoms in newborns.