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Methadone is a synthetic opioid medication used for pain management and opioid addiction treatment. It works by binding to opioid receptors in the brain and spinal cord, which helps reduce pain perception and withdrawal symptoms in people recovering from opioid dependence. Methadone has a long duration of action, making it effective for maintenance therapy, but it must be used carefully due to the risk of overdose.

Dosage of methadone varies depending on its use and the patient’s opioid tolerance. For pain management, typical oral doses start at 2.5 mg to 10 mg every 8 to 12 hours, adjusted based on response and side effects. In opioid addiction treatment, methadone is often started at 20 mg to 30 mg once daily, with careful titration to minimize withdrawal symptoms without causing over-sedation. Dosage adjustments must be made gradually, as methadone’s long half-life can lead to accumulation and toxicity if not monitored closely.

There are serious warnings associated with methadone. It can cause respiratory depression, heart rhythm problems, and overdose, especially if combined with alcohol, benzodiazepines, or other CNS depressants. Methadone has a high potential for dependence and abuse, and abrupt discontinuation may lead to withdrawal symptoms such as anxiety, muscle aches, nausea, and insomnia. Methadone should only be used under strict medical supervision, with regular monitoring for cardiac issues like QT prolongation.

Common side effects include drowsiness, dizziness, nausea, vomiting, constipation, and sweating. Less common but serious effects may involve slow or irregular heartbeat, difficulty breathing, confusion, or severe allergic reactions. Patients should seek immediate medical attention if they experience extreme drowsiness, trouble breathing, chest pain, or fainting. Due to its risks, methadone therapy requires careful dose management and frequent follow-up to ensure safety and effectiveness.