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Codeine is a prescription opioid medication used to treat mild to moderate pain and, in some cases, to suppress cough. It works by binding to opioid receptors in the brain and spinal cord, altering how the body perceives pain and reducing the urge to cough. Codeine is often combined with other medications such as acetaminophen or promethazine to enhance its effectiveness. Because it is an opioid, codeine has a risk of misuse, dependence, and addiction.

Dosage of codeine depends on the indication, patient age, and medical history. For pain relief in adults, typical doses range from 15 mg to 60 mg every 4 to 6 hours, as prescribed by a healthcare provider. For cough suppression, lower doses are generally used. Codeine should be taken exactly as directed, and patients should never exceed the prescribed amount. Children and adolescents are especially sensitive to codeine, and its use is restricted or contraindicated in many pediatric cases due to safety concerns.

There are important warnings associated with codeine use. It can cause respiratory depression, particularly at high doses or when combined with alcohol, benzodiazepines, or other central nervous system depressants. Some individuals metabolize codeine more rapidly than others, leading to dangerously high levels of morphine in the body. Codeine should be avoided in patients with breathing disorders, head injuries, or a history of substance abuse. Abrupt discontinuation after prolonged use may result in withdrawal symptoms such as restlessness, muscle aches, and irritability.

Common side effects of codeine include drowsiness, constipation, nausea, vomiting, and dizziness. Other possible effects are dry mouth, sweating, and low blood pressure. Serious side effects may include slow or shallow breathing, confusion, severe sedation, or allergic reactions such as swelling and difficulty breathing. Patients should seek immediate medical attention if they experience severe side effects or signs of an overdose.