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Ambien (zolpidem) is a non-benzodiazepine sedative-hypnotic medication specifically designed to treat insomnia by targeting GABA-A receptors in the brain to induce rapid sleep onset and improve sleep quality. It works by enhancing the inhibitory effects of GABA neurotransmitters, slowing brain activity and promoting the natural transition from wakefulness to restful sleep. Insomnia can be caused by chronic stress, anxiety disorders, depression, irregular work schedules, jet lag, poor sleep hygiene, excessive caffeine or alcohol consumption, chronic pain conditions, certain medications, underlying medical conditions like sleep apnea, or environmental factors disrupting normal sleep-wake cycles.

Ambien is available in immediate-release tablets in 5mg and 10mg strengths for helping patients fall asleep quickly, and extended-release formulations (Ambien CR) in 6.25mg and 12.5mg that feature dual-layer technology for both sleep initiation and maintenance throughout the night. The 5mg dose is typically recommended for women, elderly patients, and those with liver impairment or medication sensitivity, while 10mg is commonly prescribed for men or patients requiring stronger sedation. The medication should be taken immediately before bedtime on an empty stomach with at least 7-8 hours available for sleep, as effects begin within 15-30 minutes and insufficient sleep time can cause dangerous next-day impairment.

Common side effects include dizziness, daytime drowsiness, headache, nausea, and the distinctive risk of complex sleep-related behaviors such as sleepwalking, sleep-driving, sleep-eating, or engaging in activities without full consciousness or memory. Long-term use can lead to tolerance requiring higher doses, psychological and physical dependence, rebound insomnia when discontinued, withdrawal symptoms, and potential for misuse or abuse. Patients must never combine Ambien with alcohol or other central nervous system depressants, avoid activities requiring alertness if awakened before 7-8 hours of sleep, take only the lowest effective dose, and immediately report any unusual nighttime behaviors or memory problems to healthcare providers.