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Phentermine is a prescription appetite suppressant used for short-term weight management in individuals with obesity or those who are overweight with related health conditions such as high blood pressure or diabetes. It belongs to the sympathomimetic amine class and works by stimulating the central nervous system, helping reduce hunger and increase energy levels. Phentermine is most effective when combined with a calorie-controlled diet, exercise, and lifestyle changes.

Dosage of phentermine varies based on the formulation and individual response. Typical doses range from 15 mg to 37.5 mg once daily, usually taken before breakfast or 1–2 hours after breakfast. Some patients may be prescribed lower doses taken once or twice daily. Phentermine should be taken exactly as prescribed, and treatment is generally limited to a few weeks, as long-term use increases the risk of dependence and side effects.

There are important warnings associated with phentermine use. This medication may cause increased heart rate and elevated blood pressure, making it unsafe for individuals with heart disease, arrhythmias, stroke history, or uncontrolled hypertension. Phentermine has the potential for abuse and dependence and should not be used in patients with a history of substance misuse. It should also not be combined with MAO inhibitors, other stimulants, or certain antidepressants, as this may result in serious cardiovascular or neurological effects.

Common side effects of phentermine include dry mouth, insomnia, restlessness, nervousness, headache, and increased heart rate. Some individuals may experience constipation, irritability, or changes in mood. Serious side effects, though less common, can include chest pain, shortness of breath, severe anxiety, or swelling of the legs, which may indicate pulmonary hypertension. Patients should seek immediate medical attention if they experience severe symptoms, fainting, or signs of an allergic reaction.