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Tramadol is a prescription pain medication used to treat moderate to moderately severe pain. It is considered an opioid analgesic, but it also affects serotonin and norepinephrine levels in the brain, which helps alter the body’s pain perception. Because of this dual action, tramadol is sometimes used when other pain relievers are ineffective, though it still requires careful medical supervision.

Dosage of tramadol depends on the formulation, pain severity, and patient factors such as age and kidney or liver function. Immediate-release tablets are commonly prescribed at 50 mg to 100 mg every 4 to 6 hours as needed, with a maximum daily dose of 400 mg. Extended-release versions are taken once daily and are intended for chronic pain management. Tramadol should be taken exactly as prescribed, and doses should not be increased without medical approval to reduce the risk of serious complications.

There are important warnings associated with tramadol use. This medication carries a risk of dependence, abuse, and addiction, even when used as directed. Tramadol may increase the risk of seizures, especially in patients with a seizure disorder or those taking antidepressants, antipsychotics, or other interacting medications. Combining tramadol with alcohol, benzodiazepines, or other central nervous system depressants can cause dangerous breathing problems, coma, or death. Abrupt discontinuation may lead to withdrawal symptoms such as restlessness, anxiety, and flu-like symptoms.

Common side effects of tramadol include nausea, dizziness, drowsiness, constipation, headache, and dry mouth. Some individuals may experience sweating, itching, or loss of appetite. Serious side effects can include slowed breathing, confusion, low blood pressure, and serotonin syndrome, which may cause fever, rapid heart rate, and muscle stiffness. Patients should seek immediate medical attention if they experience difficulty breathing, severe allergic reactions, or unusual changes in mood or behavior.