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Codeine is a prescription opioid medication used to relieve mild to moderate pain, suppress cough, and sometimes manage diarrhea when other treatments are ineffective. It works by binding to opioid receptors in the brain and spinal cord, altering the perception of pain and reducing the urge to cough. Codeine is often combined with other medications such as acetaminophen or guaifenesin to enhance its effects.

The recommended dosage of codeine depends on the indication, patient age, and individual response. For pain, typical adult doses range from 15 mg to 60 mg every 4–6 hours as needed, not exceeding prescribed limits. For cough, lower doses such as 10–20 mg every 4–6 hours may be used. Codeine should be taken exactly as directed, as higher doses increase the risk of serious side effects and overdose. Children and adolescents are generally not recommended to use codeine due to safety concerns.

Common side effects include drowsiness, dizziness, nausea, vomiting, constipation, and dry mouth. Some individuals may also experience itching or lightheadedness. More serious side effects can include slow or shallow breathing, low blood pressure, confusion, and extreme sedation, which require immediate medical attention. Long-term use may lead to tolerance, physical dependence, or addiction.

There are important warnings associated with codeine use. It carries a boxed warning for respiratory depression, especially in children, older adults, and individuals with lung conditions such as asthma or COPD. Codeine should not be combined with alcohol, benzodiazepines, or other central nervous system depressants, as this can increase the risk of fatal breathing problems. Pregnant and breastfeeding individuals should avoid codeine due to risks to the baby. Careful medical supervision is essential to ensure safe and appropriate use.